Predicted to enable transmembrane transporter activity. Involved in negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway and positive regulation of cell population proliferation. Located in several cellular components, including lysosomal membrane; mitochondrion; and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for SLC35F6. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SLC35F6 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SLC35F6, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:26,503,215–26,503,885 | 260.7 kb | Distal (>10kb) Multiome | 522 | |
| chr2:26,591,548–26,592,367 | 172.2 kb | Distal (>10kb) Multiome HiCAR | 47 | |
| chr2:26,692,280–26,693,600 | 71.5 kb | Distal (>10kb) Multiome | 275 | |
| chr2:26,749,944–26,750,505 | 14.1 kb | Distal (>10kb) Multiome | 322 | |
| chr2:26,758,065–26,758,323 | 6.0 kb | Proximal (<10kb) | 470 | |
| chr2:26,764,126–26,764,575 | 6 bp | At TSS Multiome | 781 | |
| chr2:26,785,402–26,786,601 | 21.6 kb | Distal (>10kb) Multiome | 996 | |
| chr2:26,846,388–26,846,855 | 82.2 kb | Distal (>10kb) Multiome | 343 | |
| chr2:26,847,436–26,849,494 | 83.7 kb | Distal (>10kb) Multiome | 447 | |
| chr2:26,961,589–26,962,066 | 197.6 kb | Distal (>10kb) Multiome | 502 | |
| chr2:26,970,294–26,971,331 | 206.3 kb | Distal (>10kb) Multiome | 572 | |
| chr2:27,032,577–27,033,271 | 268.6 kb | Distal (>10kb) Multiome | 799 | |
| chr2:27,049,564–27,052,299 | 286.5 kb | Distal (>10kb) Multiome | 1295 |
Genomic view of the SLC35F6 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.