Glycosyltransferases, such as SLC35B4, transport nucleotide sugars from the cytoplasm where they are synthesized, to the Golgi apparatus where they are utilized in the synthesis of glycoproteins, glycolipids, and proteoglycans (Ashikov et al., 2005 [PubMed 15911612]).[supplied by OMIM, Mar 2008]
Transcription factors with Perturb-seq knockdown data for SLC35B4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SLC35B4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SLC35B4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:134,126,989–134,127,843 | 189.6 kb | Distal (>10kb) Multiome | 460 | |
| chr7:134,140,952–134,141,759 | 175.6 kb | Distal (>10kb) Multiome | 331 | |
| chr7:134,316,231–134,317,622 | 60 bp | At TSS Multiome | 905 | |
| chr7:134,432,345–134,433,248 | 115.8 kb | Distal (>10kb) Multiome | 622 | |
| chr7:134,458,208–134,459,715 | 142.2 kb | Distal (>10kb) Multiome | 797 | |
| chr7:134,547,422–134,548,048 | 230.7 kb | Distal (>10kb) Multiome | 442 |
Genomic view of the SLC35B4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.