This gene belongs to the solute carrier 2A family, which includes intracellular glucose transporters. Based on sequence comparison, the glucose transporters are grouped into three classes and this gene is a member of class II. The encoded protein, like other members of the family, contains several conserved residues and motifs and 12 transmembrane domains with both amino and carboxyl ends being on the cytosolic side of the membrane. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Nov 2012]
Transcription factors with Perturb-seq knockdown data for SLC2A8. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SLC2A8 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SLC2A8, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:127,111,996–127,112,450 | 285.0 kb | Distal (>10kb) Multiome | 160 | |
| chr9:127,122,192–127,123,298 | 274.4 kb | Distal (>10kb) Multiome | 426 | |
| chr9:127,129,382–127,130,064 | 267.6 kb | Distal (>10kb) Multiome | 117 | |
| chr9:127,199,063–127,199,676 | 197.9 kb | Distal (>10kb) Multiome | 315 | |
| chr9:127,223,725–127,226,151 | 172.4 kb | Distal (>10kb) Multiome HiCAR | 713 | |
| chr9:127,244,905–127,245,629 | 151.9 kb | Distal (>10kb) Multiome | 447 | |
| chr9:127,396,281–127,398,388 | 250 bp | At TSS Multiome | 843 | |
| chr9:127,423,809–127,424,734 | 27.1 kb | Distal (>10kb) Multiome | 791 | |
| chr9:127,450,607–127,452,473 | 54.2 kb | Distal (>10kb) Multiome | 1009 | |
| chr9:127,567,936–127,569,972 | 172.0 kb | Distal (>10kb) Multiome | 660 | |
| chr9:127,608,129–127,608,913 | 211.3 kb | Distal (>10kb) Multiome | 700 | |
| chr9:127,611,734–127,612,761 | 215.0 kb | Distal (>10kb) Multiome | 566 |
Genomic view of the SLC2A8 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.