SLC2A12 belongs to a family of transporters that catalyze the uptake of sugars through facilitated diffusion (Rogers et al., 2002). This family of transporters show conservation of 12 transmembrane helices as well as functionally significant amino acid residues (Joost and Thorens, 2001 [PubMed 11780753]).[supplied by OMIM, Mar 2008]
Transcription factors with Perturb-seq knockdown data for SLC2A12. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SLC2A12 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SLC2A12, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:133,837,635–133,838,474 | 214.6 kb | Distal (>10kb) Multiome | 508 | |
| chr6:133,888,652–133,890,259 | 163.6 kb | Distal (>10kb) Multiome | 323 | |
| chr6:133,891,167–133,891,948 | 161.0 kb | Distal (>10kb) Multiome | 305 | |
| chr6:133,916,620–133,917,311 | 135.8 kb | Distal (>10kb) Multiome | 344 | |
| chr6:133,951,916–133,953,876 | 99.5 kb | Distal (>10kb) Multiome HiCAR | 1096 | |
| chr6:134,045,333–134,045,783 | 6.8 kb | Proximal (<10kb) | 120 | |
| chr6:134,052,117–134,053,097 | 28 bp | At TSS Multiome | 520 | |
| chr6:134,074,125–134,074,941 | 21.9 kb | Distal (>10kb) Multiome | 190 | |
| chr6:134,173,985–134,177,008 | 122.4 kb | Distal (>10kb) Multiome | 1094 | |
| chr6:134,178,107–134,178,954 | 125.9 kb | Distal (>10kb) Multiome | 484 |
Genomic view of the SLC2A12 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.