The protein encoded by this gene is an isozyme of very long-chain acyl-CoA synthetase (VLCS). It is capable of activating very long-chain fatty-acids containing 24- and 26-carbons. It is expressed in liver and associated with endoplasmic reticulum but not with peroxisomes. Its primary role is in fatty acid elongation or complex lipid synthesis rather than in degradation. This gene has a mouse ortholog. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for SLC27A5. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SLC27A5 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SLC27A5, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:58,228,362–58,229,199 | 270.4 kb | Distal (>10kb) Multiome | 706 | |
| chr19:58,278,271–58,279,774 | 220.4 kb | Distal (>10kb) Multiome | 950 | |
| chr19:58,304,887–58,305,868 | 194.0 kb | Distal (>10kb) Multiome | 858 | |
| chr19:58,326,789–58,327,710 | 172.2 kb | Distal (>10kb) Multiome | 985 | |
| chr19:58,347,086–58,347,987 | 151.6 kb | Distal (>10kb) Multiome | 467 | |
| chr19:58,356,174–58,356,775 | 142.8 kb | Distal (>10kb) Multiome | 101 | |
| chr19:58,361,859–58,363,243 | 136.5 kb | Distal (>10kb) Multiome | 972 | |
| chr19:58,380,269–58,381,636 | 118.2 kb | Distal (>10kb) Multiome | 1044 | |
| chr19:58,386,311–58,387,531 | 112.2 kb | Distal (>10kb) Multiome | 1010 | |
| chr19:58,395,438–58,396,606 | 103.6 kb | Distal (>10kb) Multiome | 448 | |
| chr19:58,400,803–58,401,800 | 97.9 kb | Distal (>10kb) Multiome | 728 | |
| chr19:58,408,032–58,409,025 | 90.7 kb | Distal (>10kb) Multiome | 854 | |
| chr19:58,451,175–58,452,075 | 47.7 kb | Distal (>10kb) Multiome | 702 | |
| chr19:58,466,585–58,467,517 | 32.3 kb | Distal (>10kb) Multiome | 701 | |
| chr19:58,475,442–58,476,812 | 23.3 kb | Distal (>10kb) Multiome | 934 | |
| chr19:58,498,641–58,499,856 | 129 bp | At TSS Multiome | 939 | |
| chr19:58,513,642–58,514,431 | 14.9 kb | Distal (>10kb) Multiome | 706 | |
| chr19:58,518,851–58,520,372 | 20.5 kb | Distal (>10kb) Multiome | 1175 | |
| chr19:58,538,071–58,538,713 | 39.2 kb | Distal (>10kb) Multiome | 386 |
Genomic view of the SLC27A5 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.