This gene is one member of a family of sulfate/anion transporter genes. Family members are well conserved in gene structure and protein length yet have markedly different tissue expression patterns. This gene has abundant and specific expression in the kidney. Alternatively spliced transcript variants that encode different isoforms have been described. [provided by RefSeq, Aug 2013]
Transcription factors with Perturb-seq knockdown data for SLC26A7. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SLC26A7 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SLC26A7, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:90,984,601–90,986,072 | 264.0 kb | Distal (>10kb) Multiome | 606 | |
| chr8:91,040,121–91,041,552 | 208.5 kb | Distal (>10kb) Multiome | 777 | |
| chr8:91,069,419–91,071,048 | 179.1 kb | Distal (>10kb) Multiome | 860 | |
| chr8:91,249,164–91,249,330 | at TSS | At TSS | 55 | |
| chr8:91,253,185–91,253,558 | 3.9 kb | Proximal (<10kb) | 40 | |
| chr8:93,129,642–93,130,643 | 1880.8 kb | Distal (>10kb) Multiome HiCAR | 86 |
Genomic view of the SLC26A7 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.