This gene is a member of the mitochondrial carrier subfamily of solute carrier protein genes. The product of this gene functions as a gated pore that translocates ADP from the cytoplasm into the mitochondrial matrix and ATP from the mitochondrial matrix into the cytoplasm. The protein forms a homodimer embedded in the inner mitochondria membrane. Mutations in this gene have been shown to result in autosomal dominant progressive external opthalmoplegia and familial hypertrophic cardiomyopathy. [provided by RefSeq, Jun 2013]
Transcription factors with Perturb-seq knockdown data for SLC25A4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SLC25A4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SLC25A4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:184,983,798–184,984,312 | 159.2 kb | Distal (>10kb) Multiome | 307 | |
| chr4:185,004,689–185,005,528 | 138.1 kb | Distal (>10kb) Multiome | 348 | |
| chr4:185,018,062–185,018,650 | 124.7 kb | Distal (>10kb) Multiome HiCAR | 181 | |
| chr4:185,115,806–185,116,379 | 27.2 kb | Distal (>10kb) Multiome | 365 | |
| chr4:185,127,221–185,129,177 | 15.6 kb | Distal (>10kb) Multiome | 406 | |
| chr4:185,134,543–185,134,713 | 8.6 kb | Proximal (<10kb) | 133 | |
| chr4:185,142,664–185,143,838 | 48 bp | At TSS Multiome | 886 | |
| chr4:185,203,468–185,204,322 | 60.7 kb | Distal (>10kb) Multiome | 710 | |
| chr4:185,209,029–185,211,342 | 66.3 kb | Distal (>10kb) Multiome | 699 | |
| chr4:185,235,783–185,236,350 | 92.8 kb | Distal (>10kb) Multiome | 289 | |
| chr4:185,318,614–185,319,089 | 175.6 kb | Distal (>10kb) Multiome | 382 | |
| chr4:185,395,863–185,397,395 | 253.4 kb | Distal (>10kb) Multiome | 1140 | |
| chr4:185,425,371–185,426,547 | 282.8 kb | Distal (>10kb) Multiome | 873 |
Genomic view of the SLC25A4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.