This gene encodes a member of the SLC25 transporter or mitochondrial carrier family of proteins. Members of this family are encoded by the nuclear genome while their protein products are usually embedded in the inner mitochondrial membrane and exhibit wide-ranging substrate specificity. Although the encoded protein is currently considered an orphan transporter, this protein is related to other carriers known to transport amino acids. This protein may play a role in iron homeostasis. [provided by RefSeq, Mar 2016]
Transcription factors with Perturb-seq knockdown data for SLC25A39. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SLC25A39 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SLC25A39, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:44,066,017–44,066,857 | 258.2 kb | Distal (>10kb) Multiome | 722 | |
| chr17:44,070,107–44,071,340 | 254.0 kb | Distal (>10kb) Multiome | 1041 | |
| chr17:44,095,480–44,096,263 | 228.9 kb | Distal (>10kb) Multiome | 713 | |
| chr17:44,110,949–44,111,605 | 213.6 kb | Distal (>10kb) Multiome | 856 | |
| chr17:44,122,999–44,124,340 | 201.0 kb | Distal (>10kb) Multiome | 883 | |
| chr17:44,141,505–44,142,741 | 182.9 kb | Distal (>10kb) Multiome | 857 | |
| chr17:44,168,259–44,168,849 | 156.2 kb | Distal (>10kb) Multiome | 475 | |
| chr17:44,186,111–44,187,514 | 138.0 kb | Distal (>10kb) Multiome | 917 | |
| chr17:44,198,550–44,201,037 | 124.7 kb | Distal (>10kb) Multiome HiCAR | 868 | |
| chr17:44,210,257–44,210,930 | 114.3 kb | Distal (>10kb) Multiome HiCAR | 568 | |
| chr17:44,218,107–44,221,629 | 106.2 kb | Distal (>10kb) Multiome HiCAR | 936 | |
| chr17:44,221,765–44,222,816 | 102.5 kb | Distal (>10kb) Multiome HiCAR | 597 | |
| chr17:44,307,755–44,309,164 | 16.3 kb | Distal (>10kb) Multiome | 726 | |
| chr17:44,314,945–44,315,776 | 9.6 kb | Proximal (<10kb) Multiome | 273 | |
| chr17:44,316,273–44,316,728 | 8.3 kb | Proximal (<10kb) Multiome | 183 | |
| chr17:44,324,218–44,325,841 | 75 bp | At TSS Multiome | 852 | |
| chr17:44,326,610–44,327,149 | 2.2 kb | Proximal (<10kb) Multiome | 599 | |
| chr17:44,344,826–44,346,001 | 20.4 kb | Distal (>10kb) Multiome | 837 | |
| chr17:44,353,667–44,355,182 | 29.9 kb | Distal (>10kb) Multiome | 393 | |
| chr17:44,363,447–44,364,077 | 39.0 kb | Distal (>10kb) Multiome | 502 | |
| chr17:44,374,688–44,375,216 | 50.0 kb | Distal (>10kb) Multiome | 299 | |
| chr17:44,384,542–44,386,175 | 60.6 kb | Distal (>10kb) Multiome | 553 | |
| chr17:44,502,912–44,504,091 | 178.7 kb | Distal (>10kb) Multiome | 999 | |
| chr17:44,539,724–44,540,529 | 215.3 kb | Distal (>10kb) Multiome | 135 | |
| chr17:44,543,007–44,544,301 | 218.4 kb | Distal (>10kb) Multiome | 384 | |
| chr17:44,556,129–44,558,277 | 232.5 kb | Distal (>10kb) Multiome | 696 | |
| chr17:44,608,340–44,608,975 | 283.8 kb | Distal (>10kb) Multiome | 208 |
Genomic view of the SLC25A39 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.