This gene is a member of the mitochondrial carrier family. The encoded protein is required during erythropoiesis and is important for the biosynthesis of heme. Mutations in this gene are the cause of autosomal congenital sideroblastic anemia (anemia, sideroblastic, 2, pyridoxine-refractory). A related pseudogene is found on chromosome 1. [provided by RefSeq, Aug 2017]
Transcription factors with Perturb-seq knockdown data for SLC25A38. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SLC25A38 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SLC25A38, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:39,106,596–39,108,201 | 275.7 kb | Distal (>10kb) Multiome | 754 | |
| chr3:39,150,367–39,155,021 | 232.3 kb | Distal (>10kb) Multiome | 1014 | |
| chr3:39,177,458–39,178,406 | 205.4 kb | Distal (>10kb) Multiome | 531 | |
| chr3:39,180,469–39,181,324 | 202.4 kb | Distal (>10kb) Multiome | 541 | |
| chr3:39,288,216–39,288,885 | 94.8 kb | Distal (>10kb) Multiome | 463 | |
| chr3:39,404,841–39,405,400 | 21.7 kb | Distal (>10kb) Multiome | 137 | |
| chr3:39,406,328–39,407,246 | 23.3 kb | Distal (>10kb) Multiome | 1019 | |
| chr3:39,416,815–39,418,027 | 34.2 kb | Distal (>10kb) Multiome | 128 | |
| chr3:39,418,154–39,419,400 | 35.5 kb | Distal (>10kb) Multiome | 58 | |
| chr3:39,498,382–39,499,124 | 115.3 kb | Distal (>10kb) Multiome | 262 | |
| chr3:39,505,565–39,507,064 | 123.0 kb | Distal (>10kb) Multiome | 225 | |
| chr3:39,577,488–39,578,453 | 194.5 kb | Distal (>10kb) Multiome | 139 | |
| chr3:39,665,431–39,666,067 | 282.3 kb | Distal (>10kb) Multiome | 44 |
Genomic view of the SLC25A38 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.