Although the outer mitochondrial membrane is permeable to many small metabolites, transport of solutes across the inner mitochondrial membrane is achieved by members of the mitochondrial carrier protein family, such as SLC25A30 (Haguenauer et al., 2005 [PubMed 15809292]).[supplied by OMIM, Mar 2008]
Transcription factors with Perturb-seq knockdown data for SLC25A30. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SLC25A30 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SLC25A30, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr13:45,120,138–45,120,985 | 297.9 kb | Distal (>10kb) Multiome | 723 | |
| chr13:45,310,992–45,312,067 | 107.0 kb | Distal (>10kb) Multiome | 340 | |
| chr13:45,340,420–45,342,118 | 77.1 kb | Distal (>10kb) Multiome | 982 | |
| chr13:45,370,842–45,371,300 | 47.3 kb | Distal (>10kb) Multiome | 284 | |
| chr13:45,417,648–45,418,935 | 8 bp | At TSS Multiome | 793 | |
| chr13:45,464,608–45,465,647 | 46.5 kb | Distal (>10kb) Multiome | 854 |
Genomic view of the SLC25A30 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.