This gene encodes a member of a family of transmembrane proteins that are involved in the transport of small molecules. The encoded protein participates in the vesicular uptake, storage, and secretion of adenoside triphosphate (ATP) and other nucleotides. A mutation in this gene was found in individuals with autosomal dominant disseminated superficial actinic porokeratosis-8. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]
Transcription factors with Perturb-seq knockdown data for SLC17A9. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SLC17A9 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SLC17A9, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr20:62,793,003–62,795,717 | 158.3 kb | Distal (>10kb) Multiome | 1051 | |
| chr20:62,796,248–62,797,075 | 156.2 kb | Distal (>10kb) Multiome | 566 | |
| chr20:62,815,479–62,817,462 | 136.8 kb | Distal (>10kb) Multiome | 503 | |
| chr20:62,860,497–62,862,892 | 90.8 kb | Distal (>10kb) Multiome | 996 | |
| chr20:62,900,083–62,900,558 | 52.3 kb | Distal (>10kb) Multiome HiCAR | 764 | |
| chr20:62,925,950–62,926,856 | 26.1 kb | Distal (>10kb) Multiome | 874 | |
| chr20:62,928,980–62,929,573 | 23.4 kb | Distal (>10kb) Multiome | 289 | |
| chr20:62,937,285–62,938,569 | 14.7 kb | Distal (>10kb) Multiome | 1026 | |
| chr20:62,952,508–62,952,848 | at TSS | At TSS | 625 | |
| chr20:63,006,367–63,007,246 | 54.2 kb | Distal (>10kb) Multiome | 189 | |
| chr20:63,071,594–63,072,696 | 119.3 kb | Distal (>10kb) Multiome | 246 | |
| chr20:63,178,716–63,179,743 | 226.3 kb | Distal (>10kb) Multiome | 386 | |
| chr20:63,215,706–63,216,790 | 263.6 kb | Distal (>10kb) Multiome | 965 |
Genomic view of the SLC17A9 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.