Enables several functions, including L-histidine transmembrane transporter activity; peptide:proton symporter activity; and peptidoglycan transmembrane transporter activity. Involved in dipeptide import across plasma membrane; peptidoglycan transport; and positive regulation of pattern recognition receptor signaling pathway. Located in endolysosome membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for SLC15A4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SLC15A4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SLC15A4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:128,823,117–128,824,931 | 22 bp | At TSS Multiome | 840 | |
| chr12:128,853,166–128,854,788 | 30.3 kb | Distal (>10kb) Multiome HiCAR | 293 | |
| chr12:128,856,024–128,856,722 | 32.4 kb | Distal (>10kb) Multiome HiCAR | 116 | |
| chr12:128,858,379–128,859,438 | 35.0 kb | Distal (>10kb) Multiome HiCAR | 60 | |
| chr12:128,969,259–128,970,072 | 145.6 kb | Distal (>10kb) Multiome | 192 | |
| chr12:129,871,727–129,873,060 | 1048.3 kb | Distal (>10kb) Multiome HiCAR | 258 | |
| chr12:129,902,870–129,904,853 | 1080.3 kb | Distal (>10kb) Multiome HiCAR | 260 | |
| chr12:130,013,812–130,014,266 | 1190.2 kb | Distal (>10kb) Multiome HiCAR | 158 | |
| chr12:130,716,209–130,717,026 | 1892.6 kb | Distal (>10kb) Multiome HiCAR | 196 |
Genomic view of the SLC15A4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.