Enables dipeptide transmembrane transporter activity. Involved in dipeptide import across plasma membrane. Located in intracellular membrane-bounded organelle. [provided by Alliance of Genome Resources, Apr 2025]
Transcription factors with Perturb-seq knockdown data for SLC15A3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SLC15A3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SLC15A3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:60,775,417–60,775,969 | 176.0 kb | Distal (>10kb) Multiome | 374 | |
| chr11:60,841,541–60,842,740 | 109.6 kb | Distal (>10kb) Multiome | 839 | |
| chr11:60,852,120–60,853,076 | 98.9 kb | Distal (>10kb) Multiome | 186 | |
| chr11:60,906,047–60,907,006 | 45.0 kb | Distal (>10kb) Multiome | 787 | |
| chr11:60,913,771–60,914,957 | 37.6 kb | Distal (>10kb) Multiome | 710 | |
| chr11:60,915,279–60,915,720 | 36.0 kb | Distal (>10kb) Multiome | 296 | |
| chr11:60,923,955–60,925,328 | 27.2 kb | Distal (>10kb) Multiome | 668 | |
| chr11:60,950,921–60,951,656 | 427 bp | At TSS Multiome | 171 | |
| chr11:61,007,475–61,008,948 | 56.6 kb | Distal (>10kb) Multiome | 268 | |
| chr11:61,160,742–61,162,049 | 209.8 kb | Distal (>10kb) Multiome | 851 |
Genomic view of the SLC15A3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.