The mammalian kidney expresses a proton-coupled peptide transporter that is responsible for the absorption of small peptides, as well as beta-lactam antibiotics and other peptide-like drugs, from the tubular filtrate. This transporter, SLC15A2, belongs to the same gene family as SLC15A1 (MIM 600544), the proton-coupled peptide transporter found in the small intestine (Liu et al, 1995 [PubMed 7756356]).[supplied by OMIM, Feb 2011]
Transcription factors with Perturb-seq knockdown data for SLC15A2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SLC15A2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SLC15A2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:121,749,162–121,750,214 | 144.6 kb | Distal (>10kb) Multiome | 874 | |
| chr3:121,834,395–121,835,766 | 59.3 kb | Distal (>10kb) Multiome | 839 | |
| chr3:121,894,283–121,894,849 | 124 bp | At TSS Multiome | 105 | |
| chr3:122,021,702–122,022,458 | 127.7 kb | Distal (>10kb) Multiome | 376 | |
| chr3:122,183,580–122,184,993 | 289.9 kb | Distal (>10kb) Multiome | 224 |
Genomic view of the SLC15A2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.