Transcription factors with Perturb-seq knockdown data for SLC12A9-AS1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SLC12A9-AS1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SLC12A9-AS1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:100,569,177–100,570,642 | 283.0 kb | Distal (>10kb) Multiome | 855 | |
| chr7:100,585,161–100,587,241 | 266.2 kb | Distal (>10kb) Multiome | 966 | |
| chr7:100,611,685–100,612,981 | 240.4 kb | Distal (>10kb) Multiome | 767 | |
| chr7:100,626,427–100,627,057 | 225.9 kb | Distal (>10kb) Multiome | 415 | |
| chr7:100,656,111–100,656,626 | 196.2 kb | Distal (>10kb) Multiome | 653 | |
| chr7:100,673,043–100,674,892 | 179.1 kb | Distal (>10kb) Multiome | 934 | |
| chr7:100,674,996–100,676,406 | 176.6 kb | Distal (>10kb) Multiome | 439 | |
| chr7:100,691,570–100,692,163 | 160.8 kb | Distal (>10kb) Multiome | 364 | |
| chr7:100,693,475–100,694,667 | 158.3 kb | Distal (>10kb) Multiome | 607 | |
| chr7:100,705,140–100,706,426 | 146.7 kb | Distal (>10kb) Multiome | 962 | |
| chr7:100,827,001–100,828,324 | 25.0 kb | Distal (>10kb) Multiome | 794 | |
| chr7:100,835,906–100,837,766 | 15.0 kb | Distal (>10kb) Multiome | 766 | |
| chr7:100,852,057–100,853,190 | 158 bp | At TSS Multiome | 805 | |
| chr7:100,874,652–100,875,664 | 22.4 kb | Distal (>10kb) Multiome | 1020 | |
| chr7:100,888,882–100,891,520 | 37.3 kb | Distal (>10kb) Multiome | 1077 | |
| chr7:100,894,188–100,896,392 | 42.3 kb | Distal (>10kb) Multiome | 609 | |
| chr7:101,085,076–101,085,958 | 232.8 kb | Distal (>10kb) Multiome | 732 |
Genomic view of the SLC12A9-AS1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.