Transcription factors with Perturb-seq knockdown data for SLC12A2-DT. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SLC12A2-DT upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SLC12A2-DT, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:127,934,861–127,935,426 | 148.1 kb | Distal (>10kb) Multiome HiCAR | 524 | |
| chr5:128,081,661–128,081,788 | 1.4 kb | Proximal (<10kb) | 62 | |
| chr5:128,081,997–128,082,382 | 789 bp | At TSS | 94 | |
| chr5:128,082,728–128,084,994 | 483 bp | At TSS Multiome | 915 | |
| chr5:128,200,690–128,202,024 | 118.2 kb | Distal (>10kb) Multiome | 518 |
Genomic view of the SLC12A2-DT locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.