Enables SMAD binding activity and sequence-specific double-stranded DNA binding activity. Involved in negative regulation of transforming growth factor beta receptor signaling pathway. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for SKOR2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SKOR2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SKOR2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr18:47,246,558–47,246,906 | 4.8 kb | Proximal (<10kb) | 51 | |
| chr18:47,246,981–47,248,546 | 3.1 kb | Proximal (<10kb) | 158 | |
| chr18:47,251,397–47,251,812 | at TSS | At TSS | 173 | |
| chr18:47,254,445–47,254,917 | 2.8 kb | Proximal (<10kb) | 213 | |
| chr18:47,260,390–47,260,670 | 8.7 kb | Proximal (<10kb) | 336 | |
| chr18:47,260,995–47,261,741 | 9.3 kb | Proximal (<10kb) | 93 |
Genomic view of the SKOR2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.