Enables SMAD binding activity and sequence-specific double-stranded DNA binding activity. Involved in negative regulation of BMP signaling pathway. Located in dendrite and neuronal cell body. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for SKOR1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SKOR1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SKOR1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:67,821,026–67,821,214 | 4.3 kb | Proximal (<10kb) | 315 | |
| chr15:67,825,208–67,826,124 | at TSS | At TSS | 173 | |
| chr15:67,833,621–67,834,095 | 8.1 kb | Proximal (<10kb) | 345 | |
| chr15:67,834,628–67,835,182 | 9.1 kb | Proximal (<10kb) | 209 | |
| chr15:67,835,493–67,836,082 | 10.0 kb | Proximal (<10kb) | 135 |
Genomic view of the SKOR1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.