This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the sirtuin family. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for SIRT4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SIRT4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SIRT4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:120,086,807–120,087,619 | 215.1 kb | Distal (>10kb) Multiome | 957 | |
| chr12:120,116,125–120,117,765 | 185.4 kb | Distal (>10kb) Multiome | 903 | |
| chr12:120,194,328–120,196,208 | 107.6 kb | Distal (>10kb) Multiome | 1032 | |
| chr12:120,200,671–120,201,921 | 101.1 kb | Distal (>10kb) Multiome | 1006 | |
| chr12:120,228,170–120,231,900 | 73.7 kb | Distal (>10kb) Multiome | 1050 | |
| chr12:120,265,150–120,266,362 | 36.5 kb | Distal (>10kb) Multiome | 617 | |
| chr12:120,290,301–120,293,526 | 9.1 kb | Proximal (<10kb) Multiome | 1338 | |
| chr12:120,302,138–120,302,609 | at TSS | At TSS Multiome | 711 | |
| chr12:120,317,215–120,317,997 | 15.3 kb | Distal (>10kb) Multiome HiCAR | 872 | |
| chr12:120,361,277–120,362,299 | 59.5 kb | Distal (>10kb) Multiome | 308 | |
| chr12:120,368,637–120,370,303 | 66.9 kb | Distal (>10kb) Multiome | 250 | |
| chr12:120,388,762–120,389,560 | 86.9 kb | Distal (>10kb) Multiome | 178 | |
| chr12:120,437,436–120,438,568 | 135.7 kb | Distal (>10kb) Multiome | 725 | |
| chr12:120,445,927–120,446,970 | 144.1 kb | Distal (>10kb) Multiome | 982 | |
| chr12:120,468,864–120,470,390 | 167.4 kb | Distal (>10kb) Multiome | 942 | |
| chr12:120,495,362–120,496,939 | 193.7 kb | Distal (>10kb) Multiome | 794 | |
| chr12:120,528,856–120,529,468 | 226.8 kb | Distal (>10kb) Multiome | 849 | |
| chr12:120,534,230–120,535,077 | 232.2 kb | Distal (>10kb) Multiome | 730 | |
| chr12:120,580,919–120,581,830 | 279.1 kb | Distal (>10kb) Multiome | 736 | |
| chr12:120,584,329–120,585,045 | 282.4 kb | Distal (>10kb) Multiome | 460 |
Genomic view of the SIRT4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.