SIPA1

signal-induced proliferation-associated 1 | SPA1

The product of this gene is a mitogen induced GTPase activating protein (GAP). It exhibits a specific GAP activity for Ras-related regulatory proteins Rap1 and Rap2, but not for Ran or other small GTPases. This protein may also hamper mitogen-induced cell cycle progression when abnormally or prematurely expressed. It is localized to the perinuclear region. Two alternatively spliced variants encoding the same isoform have been characterized to date. [provided by RefSeq, Jul 2008]

Biological processes 19 terms

GTPase activator activity (GO:0005096)GTPase activator activity (GO:0005096)GTPase activator activity (GO:0005096)GTPase activator activity (GO:0005096)adaptive immune response (GO:0002250)cellular response to water deprivation (GO:0042631)cytoskeleton organization (GO:0007010)cytosol (GO:0005829)endomembrane system (GO:0012505)intracellular signal transduction (GO:0035556)negative regulation of cell adhesion (GO:0007162)negative regulation of cell cycle (GO:0045786)negative regulation of cell growth (GO:0030308)nucleus (GO:0005634)perinuclear region of cytoplasm (GO:0048471)protein binding (GO:0005515)protein-containing complex (GO:0032991)regulation of small GTPase mediated signal transduction (GO:0051056)signal transduction (GO:0007165)

Expression (TPM)

TFs regulating SIPA1 0 TFs

Transcription factors with Perturb-seq knockdown data for SIPA1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SIPA1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to SIPA1

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SIPA1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr11:65,354,023–65,355,987	283.5 kb	Distal (>10kb) Multiome	677
chr11:65,366,306–65,366,977	271.6 kb	Distal (>10kb) Multiome	309
chr11:65,381,835–65,382,758	255.9 kb	Distal (>10kb) Multiome	984
chr11:65,386,320–65,387,097	251.5 kb	Distal (>10kb) Multiome	757
chr11:65,416,383–65,417,015	221.6 kb	Distal (>10kb) Multiome	664
chr11:65,417,855–65,419,687	219.0 kb	Distal (>10kb) Multiome	1018
chr11:65,421,858–65,423,533	215.7 kb	Distal (>10kb) Multiome	1197
chr11:65,454,735–65,455,360	183.0 kb	Distal (>10kb) Multiome	573
chr11:65,477,100–65,477,990	160.6 kb	Distal (>10kb) Multiome	991
chr11:65,487,451–65,488,490	150.4 kb	Distal (>10kb) Multiome	706
chr11:65,496,515–65,498,726	140.6 kb	Distal (>10kb) Multiome	1059
chr11:65,506,702–65,508,865	130.9 kb	Distal (>10kb) Multiome	864
chr11:65,524,475–65,525,724	113.1 kb	Distal (>10kb) Multiome	711
chr11:65,538,923–65,541,339	97.3 kb	Distal (>10kb) Multiome	733
chr11:65,546,285–65,547,091	91.5 kb	Distal (>10kb) Multiome	529
chr11:65,553,318–65,554,003	84.5 kb	Distal (>10kb) Multiome	195
chr11:65,569,718–65,570,745	67.9 kb	Distal (>10kb) Multiome	930
chr11:65,571,973–65,573,008	65.7 kb	Distal (>10kb) Multiome	420
chr11:65,573,788–65,575,269	63.8 kb	Distal (>10kb) Multiome	742
chr11:65,575,601–65,576,322	62.1 kb	Distal (>10kb) Multiome	527
chr11:65,591,808–65,592,698	45.9 kb	Distal (>10kb) Multiome	169
chr11:65,606,536–65,607,917	31.0 kb	Distal (>10kb) Multiome	376
chr11:65,613,478–65,614,645	24.0 kb	Distal (>10kb) Multiome	702
chr11:65,614,954–65,616,793	22.6 kb	Distal (>10kb) Multiome	830
chr11:65,637,768–65,638,920	31 bp	At TSS Multiome	740
chr11:65,641,918–65,642,633	4.0 kb	Proximal (<10kb) Multiome	155
chr11:65,646,814–65,647,818	9.1 kb	Proximal (<10kb) Multiome	270
chr11:65,652,106–65,653,317	14.6 kb	Distal (>10kb) Multiome	901
chr11:65,662,517–65,663,930	24.9 kb	Distal (>10kb) Multiome	839
chr11:65,711,437–65,712,942	74.1 kb	Distal (>10kb) Multiome	1143
chr11:65,720,215–65,720,955	82.5 kb	Distal (>10kb) Multiome	821
chr11:65,779,808–65,781,988	141.9 kb	Distal (>10kb) Multiome	764
chr11:65,785,898–65,789,101	150.3 kb	Distal (>10kb) Multiome	478
chr11:65,817,968–65,818,502	180.1 kb	Distal (>10kb) Multiome	694
chr11:65,833,325–65,834,189	195.6 kb	Distal (>10kb) Multiome	396
chr11:65,856,804–65,858,748	218.9 kb	Distal (>10kb) Multiome	972
chr11:65,859,034–65,861,240	222.5 kb	Distal (>10kb) Multiome	1012
chr11:65,871,920–65,874,072	235.6 kb	Distal (>10kb) Multiome	741
chr11:65,887,987–65,889,162	250.4 kb	Distal (>10kb) Multiome	824
chr11:65,890,253–65,891,457	252.5 kb	Distal (>10kb) Multiome	895
chr11:65,899,867–65,900,779	262.4 kb	Distal (>10kb) Multiome	740
chr11:65,918,507–65,920,266	281.1 kb	Distal (>10kb) Multiome	992

Genome Browser

Genomic view of the SIPA1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.