SIKE interacts with IKK-epsilon (IKBKE; MIM 605048) and TBK1 (MIM 604834) and acts as a suppressor of TLR3 (MIM 603029) and virus-triggered interferon activation pathways (Huang et al., 2005 [PubMed 16281057]).[supplied by OMIM, Mar 2008]
Transcription factors with Perturb-seq knockdown data for SIKE1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SIKE1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SIKE1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:114,510,080–114,511,643 | 269.5 kb | Distal (>10kb) Multiome | 977 | |
| chr1:114,581,305–114,582,040 | 199.0 kb | Distal (>10kb) Multiome | 796 | |
| chr1:114,642,026–114,643,180 | 138.2 kb | Distal (>10kb) Multiome | 125 | |
| chr1:114,669,579–114,670,824 | 110.6 kb | Distal (>10kb) Multiome | 605 | |
| chr1:114,716,313–114,717,190 | 63.9 kb | Distal (>10kb) Multiome | 869 | |
| chr1:114,756,971–114,758,310 | 22.9 kb | Distal (>10kb) Multiome | 1005 | |
| chr1:114,780,205–114,780,915 | 23 bp | At TSS Multiome | 869 |
Genomic view of the SIKE1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.