Predicted to enable GABA receptor binding activity and ionotropic glutamate receptor binding activity. Predicted to be involved in several processes, including gamma-aminobutyric acid receptor clustering; positive regulation of long-term synaptic potentiation; and regulation of signaling receptor activity. Predicted to be located in asymmetric, glutamatergic, excitatory synapse. Predicted to be active in glutamatergic synapse; postsynaptic density; and synaptic membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for SHISA7. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SHISA7 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SHISA7, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:55,437,462–55,437,654 | 5.6 kb | Proximal (<10kb) | 481 | |
| chr19:55,440,433–55,440,687 | 2.6 kb | Proximal (<10kb) | 117 | |
| chr19:55,440,796–55,440,998 | 2.3 kb | Proximal (<10kb) | 158 | |
| chr19:55,442,036–55,442,408 | 891 bp | At TSS | 148 | |
| chr19:55,452,738–55,453,308 | 9.4 kb | Proximal (<10kb) | 339 |
Genomic view of the SHISA7 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.