This gene is an interferon stimulated gene (ISG) that inhibits viral replication. The encoded protein binds nucleic acids and inhibits programmed -1 ribosomal frameshifting required for translation by many RNA viruses. Viruses inhibited by the protein include Zika virus, dengue virus and the coronaviruses, SARS-CoV and SARS-CoV2. [provided by RefSeq, Aug 2021]
Transcription factors with Perturb-seq knockdown data for SHFL. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SHFL upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SHFL, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:9,791,515–9,793,483 | 293.6 kb | Distal (>10kb) Multiome | 507 | |
| chr19:9,818,302–9,820,113 | 267.0 kb | Distal (>10kb) Multiome | 870 | |
| chr19:9,827,304–9,828,194 | 258.5 kb | Distal (>10kb) Multiome | 742 | |
| chr19:9,834,598–9,835,806 | 251.2 kb | Distal (>10kb) Multiome | 681 | |
| chr19:9,914,501–9,914,999 | 171.5 kb | Distal (>10kb) Multiome | 587 | |
| chr19:9,933,993–9,934,841 | 152.0 kb | Distal (>10kb) Multiome | 425 | |
| chr19:9,935,627–9,937,234 | 149.8 kb | Distal (>10kb) Multiome | 297 | |
| chr19:10,027,570–10,028,022 | 58.5 kb | Distal (>10kb) Multiome | 753 | |
| chr19:10,086,000–10,086,942 | 53 bp | At TSS Multiome | 614 | |
| chr19:10,095,848–10,096,951 | 9.9 kb | Proximal (<10kb) Multiome | 572 | |
| chr19:10,106,123–10,106,748 | 20.0 kb | Distal (>10kb) Multiome | 842 | |
| chr19:10,113,011–10,113,478 | 26.8 kb | Distal (>10kb) Multiome | 511 | |
| chr19:10,119,464–10,120,287 | 33.6 kb | Distal (>10kb) Multiome | 818 | |
| chr19:10,194,229–10,195,372 | 108.6 kb | Distal (>10kb) Multiome | 939 | |
| chr19:10,230,671–10,231,665 | 145.0 kb | Distal (>10kb) Multiome | 595 | |
| chr19:10,251,723–10,252,663 | 165.7 kb | Distal (>10kb) Multiome | 969 | |
| chr19:10,270,913–10,271,370 | 184.8 kb | Distal (>10kb) Multiome | 753 | |
| chr19:10,286,849–10,287,511 | 200.7 kb | Distal (>10kb) Multiome | 621 | |
| chr19:10,288,709–10,290,833 | 203.2 kb | Distal (>10kb) Multiome | 688 | |
| chr19:10,292,085–10,293,198 | 206.1 kb | Distal (>10kb) Multiome | 441 | |
| chr19:10,315,359–10,316,478 | 229.6 kb | Distal (>10kb) Multiome | 830 | |
| chr19:10,332,816–10,334,107 | 247.2 kb | Distal (>10kb) Multiome | 882 | |
| chr19:10,334,573–10,335,642 | 248.7 kb | Distal (>10kb) Multiome | 584 | |
| chr19:10,352,359–10,354,435 | 266.4 kb | Distal (>10kb) Multiome | 447 | |
| chr19:10,380,209–10,381,218 | 294.3 kb | Distal (>10kb) Multiome | 874 |
Genomic view of the SHFL locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.