Enables guanyl-nucleotide exchange factor activity. Predicted to be involved in intracellular signal transduction. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for SH3BP5L. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SH3BP5L upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SH3BP5L, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:247,356,823–247,358,156 | 1468.7 kb | Distal (>10kb) Multiome HiCAR | 296 | |
| chr1:247,376,539–247,377,867 | 1449.0 kb | Distal (>10kb) Multiome HiCAR | 164 | |
| chr1:247,389,944–247,390,543 | 1435.6 kb | Distal (>10kb) Multiome HiCAR | 451 | |
| chr1:247,638,798–247,639,973 | 1186.4 kb | Distal (>10kb) Multiome HiCAR | 288 | |
| chr1:248,825,287–248,827,024 | 220 bp | At TSS Multiome | 866 | |
| chr1:248,837,447–248,839,602 | 12.3 kb | Distal (>10kb) Multiome | 979 | |
| chr1:248,847,039–248,848,710 | 21.7 kb | Distal (>10kb) Multiome | 242 | |
| chr1:248,857,587–248,859,802 | 33.1 kb | Distal (>10kb) Multiome | 984 | |
| chr1:248,862,776–248,863,977 | 37.4 kb | Distal (>10kb) Multiome | 625 | |
| chr1:248,872,599–248,874,733 | 48.1 kb | Distal (>10kb) Multiome | 1099 | |
| chr1:248,905,646–248,907,461 | 80.5 kb | Distal (>10kb) Multiome | 1045 |
Genomic view of the SH3BP5L locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.