SH2D5

SH2 domain containing 5

Predicted to be located in synapse. Predicted to be active in postsynaptic density. [provided by Alliance of Genome Resources, Jul 2025]

Biological processes 4 terms

postsynaptic density (GO:0014069)postsynaptic density (GO:0014069)postsynaptic density (GO:0014069)protein binding (GO:0005515)

Expression (TPM)

TFs regulating SH2D5 0 TFs

Transcription factors with Perturb-seq knockdown data for SH2D5. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SH2D5 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to SH2D5

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SH2D5, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr1:20,485,233–20,485,959	246.4 kb	Distal (>10kb) Multiome	348
chr1:20,486,131–20,487,438	245.3 kb	Distal (>10kb) Multiome	760
chr1:20,493,822–20,494,241	238.2 kb	Distal (>10kb) Multiome	430
chr1:20,507,717–20,508,432	224.2 kb	Distal (>10kb) Multiome	811
chr1:20,552,019–20,553,890	178.6 kb	Distal (>10kb) Multiome	518
chr1:20,625,186–20,625,881	106.8 kb	Distal (>10kb) Multiome	123
chr1:20,633,024–20,634,989	98.5 kb	Distal (>10kb) Multiome	759
chr1:20,661,099–20,662,130	70.7 kb	Distal (>10kb) Multiome	784
chr1:20,696,319–20,697,384	35.4 kb	Distal (>10kb) Multiome	727
chr1:20,717,384–20,718,370	14.4 kb	Distal (>10kb) Multiome	440
chr1:20,731,726–20,733,330	19 bp	At TSS Multiome	718
chr1:20,786,021–20,787,857	54.6 kb	Distal (>10kb) Multiome	963

Genome Browser

Genomic view of the SH2D5 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.