The protein encoded by this gene is expressed in B lymphocytes and contains pleckstrin homology and src homology 2 (SH2) domains. In Burkitt's lymphoma cell lines, it is tyrosine-phosphorylated in response to B cell receptor stimulation. Because it binds Shc independent of stimulation and Grb2 after stimulation, it appears to play a role in signal transduction from the receptor to the Shc/Grb2 pathway. [provided by RefSeq, Jun 2009]
Transcription factors with Perturb-seq knockdown data for SH2B2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SH2B2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SH2B2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:101,411,116–101,411,868 | 875.5 kb | Distal (>10kb) Multiome HiCAR | 307 | |
| chr7:101,602,457–101,603,098 | 684.2 kb | Distal (>10kb) Multiome HiCAR | 367 | |
| chr7:101,688,200–101,688,846 | 598.4 kb | Distal (>10kb) Multiome HiCAR | 537 | |
| chr7:102,248,441–102,249,220 | 38.0 kb | Distal (>10kb) Multiome | 131 | |
| chr7:102,279,522–102,279,902 | 7.0 kb | Proximal (<10kb) | 378 | |
| chr7:102,285,837–102,288,098 | 25 bp | At TSS Multiome | 792 | |
| chr7:102,300,749–102,301,273 | 14.2 kb | Distal (>10kb) Multiome | 175 | |
| chr7:102,363,388–102,364,334 | 76.9 kb | Distal (>10kb) Multiome | 479 | |
| chr7:102,395,663–102,396,959 | 109.3 kb | Distal (>10kb) Multiome HiCAR | 874 | |
| chr7:102,432,870–102,434,057 | 146.6 kb | Distal (>10kb) Multiome | 553 | |
| chr7:102,464,403–102,465,431 | 178.1 kb | Distal (>10kb) Multiome | 854 |
Genomic view of the SH2B2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.