Transcription factors with Perturb-seq knockdown data for SFTA1P. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SFTA1P upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SFTA1P, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:10,792,591–10,792,980 | 1.9 kb | Proximal (<10kb) | 105 | |
| chr10:10,794,646–10,795,248 | at TSS | At TSS | 175 | |
| chr10:10,796,531–10,797,105 | 1.6 kb | Proximal (<10kb) | 96 | |
| chr10:10,798,171–10,799,033 | 3.3 kb | Proximal (<10kb) | 84 |
Genomic view of the SFTA1P locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.