Enables transcription coactivator activity. Involved in cellular response to estrogen stimulus; double-strand break repair via homologous recombination; and positive regulation of DNA-templated transcription. Located in centrosome; nucleolus; and nucleoplasm. Part of Swi5-Sfr1 complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for SFR1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SFR1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SFR1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:103,829,792–103,830,463 | 292.0 kb | Distal (>10kb) Multiome | 65 | |
| chr10:103,836,976–103,837,450 | 284.9 kb | Distal (>10kb) Multiome | 52 | |
| chr10:103,839,572–103,841,382 | 281.8 kb | Distal (>10kb) Multiome | 306 | |
| chr10:103,854,330–103,856,292 | 266.5 kb | Distal (>10kb) Multiome | 649 | |
| chr10:103,917,536–103,919,139 | 203.8 kb | Distal (>10kb) Multiome | 926 | |
| chr10:103,966,618–103,967,712 | 155.0 kb | Distal (>10kb) Multiome | 758 | |
| chr10:104,045,227–104,046,125 | 76.6 kb | Distal (>10kb) Multiome | 116 | |
| chr10:104,057,535–104,058,241 | 64.3 kb | Distal (>10kb) Multiome | 66 | |
| chr10:104,120,766–104,122,782 | 215 bp | At TSS Multiome | 959 | |
| chr10:104,127,443–104,127,755 | 5.3 kb | Proximal (<10kb) | 112 | |
| chr10:104,155,284–104,156,268 | 33.7 kb | Distal (>10kb) Multiome | 175 | |
| chr10:104,231,576–104,232,903 | 110.2 kb | Distal (>10kb) Multiome | 777 | |
| chr10:104,252,389–104,254,221 | 131.2 kb | Distal (>10kb) Multiome | 583 | |
| chr10:104,254,370–104,255,379 | 132.7 kb | Distal (>10kb) Multiome | 714 | |
| chr10:104,268,486–104,269,500 | 146.9 kb | Distal (>10kb) Multiome | 569 | |
| chr10:104,274,546–104,275,629 | 152.8 kb | Distal (>10kb) Multiome | 513 | |
| chr10:104,291,224–104,291,975 | 169.4 kb | Distal (>10kb) Multiome | 512 | |
| chr10:104,305,412–104,306,052 | 183.6 kb | Distal (>10kb) Multiome | 394 | |
| chr10:104,328,024–104,329,489 | 206.7 kb | Distal (>10kb) Multiome | 537 | |
| chr10:104,331,220–104,332,050 | 209.4 kb | Distal (>10kb) Multiome | 374 | |
| chr10:104,337,560–104,339,351 | 216.3 kb | Distal (>10kb) Multiome | 762 | |
| chr10:104,353,170–104,354,177 | 231.5 kb | Distal (>10kb) Multiome | 470 |
Genomic view of the SFR1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.