SFN

stratifin | YWHAS

This gene encodes a cell cycle checkpoint protein. The encoded protein binds to translation and initiation factors and functions as a regulator of mitotic translation. In response to DNA damage this protein plays a role in preventing DNA errors during mitosis. [provided by RefSeq, Aug 2017]

Biological processes 43 terms

cAMP/PKA signal transduction (GO:0141156)cadherin binding (GO:0045296)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytosol (GO:0005829)cytosol (GO:0005829)cytosol (GO:0005829)establishment of skin barrier (GO:0061436)establishment of skin barrier (GO:0061436)extracellular exosome (GO:0070062)extracellular region (GO:0005576)extracellular region (GO:0005576)identical protein binding (GO:0042802)identical protein binding (GO:0042802)intracellular protein localization (GO:0008104)intrinsic apoptotic signaling pathway in response to DNA damage (GO:0008630)negative regulation of innate immune response (GO:0045824)negative regulation of protein kinase activity (GO:0006469)negative regulation of protein localization to plasma membrane (GO:1903077)nucleus (GO:0005634)nucleus (GO:0005634)phosphoprotein binding (GO:0051219)phosphoserine residue binding (GO:0050815)positive regulation of cell adhesion (GO:0045785)positive regulation of cell growth (GO:0030307)positive regulation of epidermal cell differentiation (GO:0045606)positive regulation of epidermal cell differentiation (GO:0045606)positive regulation of protein export from nucleus (GO:0046827)positive regulation of protein localization (GO:1903829)protein binding (GO:0005515)protein export from nucleus (GO:0006611)protein kinase C inhibitor activity (GO:0008426)protein kinase binding (GO:0019901)protein kinase binding (GO:0019901)protein sequestering activity (GO:0140311)regulation of cell-cell adhesion (GO:0022407)regulation of epidermal cell division (GO:0010482)regulation of epidermal cell division (GO:0010482)regulation of protein localization (GO:0032880)release of cytochrome c from mitochondria (GO:0001836)signal transduction (GO:0007165)signal transduction (GO:0007165)

Expression (TPM)

TFs regulating SFN 0 TFs

Transcription factors with Perturb-seq knockdown data for SFN. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SFN upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to SFN

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SFN, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr1:26,620,089–26,621,718	242.4 kb	Distal (>10kb) Multiome	1174
chr1:26,692,203–26,693,499	170.1 kb	Distal (>10kb) Multiome	974
chr1:26,695,271–26,696,473	167.4 kb	Distal (>10kb) Multiome	1053
chr1:26,723,135–26,723,892	139.6 kb	Distal (>10kb) Multiome	671
chr1:26,786,686–26,788,664	75.2 kb	Distal (>10kb) Multiome	918
chr1:26,826,166–26,827,148	36.5 kb	Distal (>10kb) Multiome	510
chr1:26,862,775–26,863,565	149 bp	At TSS Multiome	486
chr1:26,864,355–26,865,945	2.1 kb	Proximal (<10kb) Multiome	892
chr1:26,889,797–26,890,628	27.1 kb	Distal (>10kb) Multiome	906
chr1:26,899,986–26,900,610	37.2 kb	Distal (>10kb) Multiome	792
chr1:26,921,268–26,922,160	58.5 kb	Distal (>10kb) Multiome	838
chr1:26,959,908–26,960,855	97.3 kb	Distal (>10kb) Multiome	607
chr1:26,992,986–26,995,593	130.4 kb	Distal (>10kb) Multiome	854
chr1:26,997,489–26,998,161	134.7 kb	Distal (>10kb) Multiome	550
chr1:27,010,686–27,011,820	148.1 kb	Distal (>10kb) Multiome	379
chr1:27,012,151–27,013,639	149.9 kb	Distal (>10kb) Multiome	712
chr1:27,031,351–27,031,956	168.5 kb	Distal (>10kb) Multiome	260
chr1:27,154,381–27,155,711	292.0 kb	Distal (>10kb) Multiome	1038

Genome Browser

Genomic view of the SFN locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.