This gene encodes a fusion protein that contains an N-terminal histone-lysine N-methyltransferase domain and a C-terminal mariner transposase domain. The encoded protein binds DNA and functions in DNA repair activities including non-homologous end joining and double strand break repair. The SET domain portion of this protein specifically methylates histone H3 lysines 4 and 36. This gene exists as a fusion gene only in anthropoid primates, other organisms lack mariner transposase domain. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]
Transcription factors with Perturb-seq knockdown data for SETMAR. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SETMAR upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SETMAR, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:3,179,188–3,180,181 | 1123.6 kb | Distal (>10kb) Multiome HiCAR | 973 | |
| chr3:3,625,339–3,626,225 | 677.7 kb | Distal (>10kb) Multiome HiCAR | 142 | |
| chr3:4,071,181–4,072,083 | 231.7 kb | Distal (>10kb) Multiome | 153 | |
| chr3:4,302,729–4,304,211 | 107 bp | At TSS Multiome | 854 | |
| chr3:4,466,545–4,467,641 | 163.8 kb | Distal (>10kb) Multiome | 998 | |
| chr3:4,492,176–4,494,554 | 189.9 kb | Distal (>10kb) Multiome | 1013 | |
| chr3:4,512,911–4,513,573 | 209.8 kb | Distal (>10kb) Multiome | 356 | |
| chr3:4,628,901–4,629,960 | 326.2 kb | Distal (>10kb) Multiome HiCAR | 233 |
Genomic view of the SETMAR locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.