This gene encodes a methyltransferase that adds a methyl group to the histone H2AZ, which is involved in nuclear receptor-dependent transcription. The protein also interacts with several endogenous proteins which are involved in nuclear hormone receptor signaling. A related pseudogene is located on chromosome 2. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
Transcription factors with Perturb-seq knockdown data for SETD6. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SETD6 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SETD6, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:58,236,247–58,236,852 | 278.9 kb | Distal (>10kb) Multiome | 355 | |
| chr16:58,249,584–58,250,557 | 265.5 kb | Distal (>10kb) Multiome | 641 | |
| chr16:58,392,269–58,393,124 | 122.9 kb | Distal (>10kb) Multiome | 993 | |
| chr16:58,463,143–58,465,363 | 51.8 kb | Distal (>10kb) Multiome | 307 | |
| chr16:58,487,547–58,488,283 | 27.7 kb | Distal (>10kb) Multiome | 523 | |
| chr16:58,499,699–58,500,457 | 15.5 kb | Distal (>10kb) Multiome | 283 | |
| chr16:58,500,548–58,502,121 | 14.1 kb | Distal (>10kb) Multiome | 481 | |
| chr16:58,511,772–58,512,394 | 3.4 kb | Proximal (<10kb) Multiome | 355 | |
| chr16:58,515,027–58,516,681 | 55 bp | At TSS Multiome | 1010 | |
| chr16:58,629,310–58,630,709 | 114.7 kb | Distal (>10kb) Multiome HiCAR | 1050 | |
| chr16:58,684,159–58,685,101 | 169.2 kb | Distal (>10kb) Multiome | 695 | |
| chr16:58,733,415–58,734,721 | 218.7 kb | Distal (>10kb) Multiome | 1031 | |
| chr16:58,756,000–58,756,694 | 241.0 kb | Distal (>10kb) Multiome | 352 |
Genomic view of the SETD6 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.