The protein encoded by this gene was identified in a yeast two-hybrid assay employing the second subunit of human replication protein A as bait. It is localized to the nucleus and its expression is significantly higher in cancer cell lines compared to normal cell lines. This protein has also been shown to be a strong transcriptional co-activator. Alternative splicing has been observed at this locus and two variants, both encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for SERTAD3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SERTAD3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SERTAD3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:40,190,883–40,192,408 | 252.4 kb | Distal (>10kb) Multiome | 764 | |
| chr19:40,217,060–40,217,642 | 227.0 kb | Distal (>10kb) Multiome | 366 | |
| chr19:40,284,527–40,285,917 | 158.9 kb | Distal (>10kb) Multiome | 913 | |
| chr19:40,347,917–40,348,964 | 95.7 kb | Distal (>10kb) Multiome | 843 | |
| chr19:40,365,649–40,366,111 | 78.4 kb | Distal (>10kb) Multiome | 244 | |
| chr19:40,398,541–40,399,285 | 45.3 kb | Distal (>10kb) Multiome | 234 | |
| chr19:40,403,323–40,404,681 | 40.6 kb | Distal (>10kb) Multiome | 638 | |
| chr19:40,420,702–40,421,699 | 23.1 kb | Distal (>10kb) Multiome | 966 | |
| chr19:40,424,783–40,426,631 | 18.3 kb | Distal (>10kb) Multiome | 954 | |
| chr19:40,433,505–40,434,546 | 10.3 kb | Distal (>10kb) Multiome | 791 | |
| chr19:40,442,698–40,445,144 | 1.1 kb | Proximal (<10kb) Multiome | 994 | |
| chr19:40,445,964–40,446,232 | 1.9 kb | Proximal (<10kb) | 219 | |
| chr19:40,465,326–40,466,635 | 21.6 kb | Distal (>10kb) Multiome | 815 | |
| chr19:40,487,850–40,488,306 | 43.8 kb | Distal (>10kb) Multiome | 193 | |
| chr19:40,519,457–40,519,993 | 75.4 kb | Distal (>10kb) Multiome | 222 | |
| chr19:40,528,978–40,529,879 | 85.0 kb | Distal (>10kb) Multiome | 601 | |
| chr19:40,529,987–40,530,863 | 86.4 kb | Distal (>10kb) Multiome | 384 | |
| chr19:40,549,036–40,549,555 | 105.1 kb | Distal (>10kb) Multiome | 372 | |
| chr19:40,570,181–40,571,253 | 126.5 kb | Distal (>10kb) Multiome | 598 | |
| chr19:40,576,133–40,577,495 | 132.6 kb | Distal (>10kb) Multiome | 616 | |
| chr19:40,596,828–40,597,429 | 152.8 kb | Distal (>10kb) Multiome | 354 | |
| chr19:40,598,094–40,598,871 | 154.3 kb | Distal (>10kb) Multiome | 606 | |
| chr19:40,603,345–40,604,624 | 159.8 kb | Distal (>10kb) Multiome | 889 | |
| chr19:40,604,983–40,606,597 | 161.5 kb | Distal (>10kb) Multiome | 708 | |
| chr19:40,609,543–40,610,691 | 165.8 kb | Distal (>10kb) Multiome | 519 | |
| chr19:40,612,884–40,615,179 | 169.4 kb | Distal (>10kb) Multiome | 595 | |
| chr19:40,623,557–40,624,516 | 179.8 kb | Distal (>10kb) Multiome | 454 | |
| chr19:40,634,333–40,634,959 | 190.3 kb | Distal (>10kb) Multiome | 629 | |
| chr19:40,662,838–40,663,654 | 218.8 kb | Distal (>10kb) Multiome | 856 | |
| chr19:40,689,888–40,691,759 | 246.5 kb | Distal (>10kb) Multiome | 691 | |
| chr19:40,714,822–40,715,454 | 270.9 kb | Distal (>10kb) Multiome | 531 | |
| chr19:40,716,605–40,717,875 | 272.8 kb | Distal (>10kb) Multiome | 772 |
Genomic view of the SERTAD3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.