Predicted to enable guanyl-nucleotide exchange factor activity. Involved in negative regulation of protein secretion. Located in cytosol and nucleoplasm. Biomarker of atherosclerosis. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for SERGEF. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SERGEF upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SERGEF, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:17,718,983–17,721,083 | 292.7 kb | Distal (>10kb) Multiome | 275 | |
| chr11:17,730,654–17,731,349 | 282.0 kb | Distal (>10kb) Multiome | 297 | |
| chr11:17,734,340–17,735,554 | 278.1 kb | Distal (>10kb) Multiome | 419 | |
| chr11:18,012,267–18,014,143 | 43 bp | At TSS Multiome | 838 | |
| chr11:18,105,744–18,106,263 | 93.0 kb | Distal (>10kb) Multiome | 873 |
Genomic view of the SERGEF locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.