The amino acid selenocysteine is the only amino acid that does not have its own tRNA synthetase. Instead, this amino acid is synthesized on its cognate tRNA in a three step process. The protein encoded by this gene catalyzes the third step in the process, the conversion of O-phosphoseryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec).[provided by RefSeq, Mar 2011]
Transcription factors with Perturb-seq knockdown data for SEPSECS. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SEPSECS upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SEPSECS, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:24,912,021–24,913,398 | 247.8 kb | Distal (>10kb) Multiome | 420 | |
| chr4:24,988,783–24,989,362 | 171.6 kb | Distal (>10kb) Multiome | 120 | |
| chr4:25,030,155–25,031,590 | 129.6 kb | Distal (>10kb) Multiome | 304 | |
| chr4:25,081,936–25,082,684 | 78.2 kb | Distal (>10kb) Multiome | 92 | |
| chr4:25,131,511–25,132,461 | 28.5 kb | Distal (>10kb) Multiome | 74 | |
| chr4:25,159,654–25,161,108 | 90 bp | At TSS Multiome | 899 | |
| chr4:25,233,604–25,234,892 | 73.5 kb | Distal (>10kb) Multiome | 812 | |
| chr4:25,312,481–25,313,179 | 152.2 kb | Distal (>10kb) Multiome | 951 | |
| chr4:25,376,361–25,378,027 | 216.6 kb | Distal (>10kb) Multiome HiCAR | 760 |
Genomic view of the SEPSECS locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.