This gene encodes a nucleolar protein, which belongs to the SelWTH family. It functions as an oxidoreductase, and has been shown to protect neurons against UVB-induced damage by inhibiting apoptotic cell death pathways, promote mitochondrial biogenesis and mitochondrial function, and suppress cellular senescence through genome maintenance and redox regulation. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, May 2016]
Transcription factors with Perturb-seq knockdown data for SELENOH. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SELENOH upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SELENOH, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:57,457,029–57,457,825 | 284.0 kb | Distal (>10kb) Multiome | 458 | |
| chr11:57,460,127–57,461,576 | 280.9 kb | Distal (>10kb) Multiome | 418 | |
| chr11:57,480,236–57,481,014 | 261.0 kb | Distal (>10kb) Multiome | 300 | |
| chr11:57,482,336–57,483,518 | 258.4 kb | Distal (>10kb) Multiome | 338 | |
| chr11:57,493,430–57,494,126 | 247.8 kb | Distal (>10kb) Multiome | 521 | |
| chr11:57,499,261–57,500,331 | 241.7 kb | Distal (>10kb) Multiome | 548 | |
| chr11:57,514,003–57,516,118 | 227.0 kb | Distal (>10kb) Multiome | 833 | |
| chr11:57,530,326–57,531,572 | 210.6 kb | Distal (>10kb) Multiome | 824 | |
| chr11:57,567,377–57,568,664 | 173.4 kb | Distal (>10kb) Multiome | 665 | |
| chr11:57,597,419–57,598,821 | 143.4 kb | Distal (>10kb) Multiome | 359 | |
| chr11:57,637,508–57,640,656 | 103.3 kb | Distal (>10kb) Multiome | 699 | |
| chr11:57,644,541–57,645,304 | 96.5 kb | Distal (>10kb) Multiome | 237 | |
| chr11:57,646,682–57,652,802 | 91.6 kb | Distal (>10kb) Multiome | 580 | |
| chr11:57,656,843–57,658,231 | 83.9 kb | Distal (>10kb) Multiome | 827 | |
| chr11:57,666,634–57,668,805 | 73.7 kb | Distal (>10kb) Multiome | 958 | |
| chr11:57,711,417–57,713,054 | 29.2 kb | Distal (>10kb) Multiome | 857 | |
| chr11:57,735,791–57,736,486 | 5.0 kb | Proximal (<10kb) | 135 | |
| chr11:57,740,872–57,742,140 | 66 bp | At TSS Multiome | 973 | |
| chr11:57,761,276–57,762,144 | 20.3 kb | Distal (>10kb) Multiome | 612 | |
| chr11:57,778,066–57,779,000 | 37.2 kb | Distal (>10kb) Multiome | 688 | |
| chr11:57,780,962–57,781,951 | 40.1 kb | Distal (>10kb) Multiome | 317 | |
| chr11:57,800,273–57,801,159 | 59.3 kb | Distal (>10kb) Multiome HiCAR | 547 | |
| chr11:57,902,618–57,904,039 | 161.8 kb | Distal (>10kb) Multiome | 362 |
Genomic view of the SELENOH locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.