The protein encoded by this gene is one of the essential components of the machinery involved in co-translational insertion of selenocysteine (Sec) into selenoproteins. Sec is encoded by the UGA codon, which normally signals translation termination. The recoding of UGA as Sec codon requires a Sec insertion sequence (SECIS) element; present in the 3' untranslated regions of eukaryotic selenoprotein mRNAs. This protein specifically binds to the SECIS element, which is stimulated by a Sec-specific translation elongation factor. Mutations in this gene have been associated with reduction in enzymatic activity of type II iodothyronine deiodinase (a selenoprotein) and abnormal thyroid hormone metabolism. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2017]
Transcription factors with Perturb-seq knockdown data for SECISBP2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SECISBP2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SECISBP2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:89,179,706–89,180,739 | 138.5 kb | Distal (>10kb) Multiome | 598 | |
| chr9:89,225,983–89,226,479 | 92.5 kb | Distal (>10kb) Multiome | 72 | |
| chr9:89,295,298–89,295,875 | 23.3 kb | Distal (>10kb) Multiome | 98 | |
| chr9:89,309,551–89,310,009 | 8.5 kb | Proximal (<10kb) | 181 | |
| chr9:89,310,238–89,311,866 | 7.9 kb | Proximal (<10kb) Multiome | 945 | |
| chr9:89,317,972–89,319,093 | 201 bp | At TSS Multiome | 1083 | |
| chr9:89,435,291–89,435,862 | 116.7 kb | Distal (>10kb) Multiome | 216 | |
| chr9:89,497,231–89,498,509 | 179.2 kb | Distal (>10kb) Multiome | 374 | |
| chr9:89,603,012–89,604,575 | 284.3 kb | Distal (>10kb) Multiome | 537 | |
| chr9:89,604,751–89,607,232 | 287.9 kb | Distal (>10kb) Multiome | 689 |
Genomic view of the SECISBP2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.