The protein encoded by this gene is a member of the SEC23 subfamily of the SEC23/SEC24 family, which is involved in vesicle trafficking. The encoded protein has similarity to yeast Sec23p component of COPII. COPII is the coat protein complex responsible for vesicle budding from the ER. The function of this gene product has been implicated in cargo selection and concentration. Multiple alternatively spliced transcript variants have been identified in this gene. [provided by RefSeq, Feb 2010]
Transcription factors with Perturb-seq knockdown data for SEC23B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SEC23B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SEC23B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr20:18,287,674–18,288,982 | 219.2 kb | Distal (>10kb) Multiome | 971 | |
| chr20:18,413,071–18,413,534 | 94.2 kb | Distal (>10kb) Multiome | 167 | |
| chr20:18,466,666–18,467,699 | 40.4 kb | Distal (>10kb) Multiome | 930 | |
| chr20:18,496,758–18,497,430 | 10.4 kb | Distal (>10kb) Multiome | 820 | |
| chr20:18,507,260–18,508,352 | 160 bp | At TSS Multiome | 959 | |
| chr20:18,566,948–18,567,920 | 59.8 kb | Distal (>10kb) Multiome | 957 | |
| chr20:18,587,564–18,588,839 | 80.4 kb | Distal (>10kb) Multiome | 882 | |
| chr20:18,793,728–18,794,660 | 286.6 kb | Distal (>10kb) Multiome | 767 | |
| chr20:19,757,220–19,759,328 | 1250.5 kb | Distal (>10kb) Multiome HiCAR | 839 | |
| chr20:20,016,869–20,017,994 | 1509.7 kb | Distal (>10kb) Multiome HiCAR | 994 |
Genomic view of the SEC23B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.