This gene encodes a member of the short-chain dehydrogenases/reductases (SDR) superfamily, which includes both classical and extended types. The encoded protein represents an extended type, with similarity to epimerases. Alternatively spliced transcript variants that encode different protein isoforms have been described. [provided by RefSeq, Mar 2014]
Transcription factors with Perturb-seq knockdown data for SDR39U1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SDR39U1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SDR39U1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:24,146,204–24,148,108 | 295.9 kb | Distal (>10kb) Multiome | 918 | |
| chr14:24,160,877–24,161,762 | 281.5 kb | Distal (>10kb) Multiome | 970 | |
| chr14:24,171,489–24,172,698 | 270.9 kb | Distal (>10kb) Multiome | 365 | |
| chr14:24,188,229–24,189,111 | 253.9 kb | Distal (>10kb) Multiome | 1074 | |
| chr14:24,195,072–24,196,365 | 247.2 kb | Distal (>10kb) Multiome | 1059 | |
| chr14:24,212,871–24,213,884 | 229.3 kb | Distal (>10kb) Multiome | 1036 | |
| chr14:24,215,523–24,216,241 | 226.7 kb | Distal (>10kb) Multiome | 955 | |
| chr14:24,231,706–24,233,147 | 210.2 kb | Distal (>10kb) Multiome | 1027 | |
| chr14:24,241,845–24,243,572 | 200.2 kb | Distal (>10kb) Multiome | 1077 | |
| chr14:24,270,770–24,271,924 | 171.3 kb | Distal (>10kb) Multiome | 1089 | |
| chr14:24,299,120–24,300,273 | 143.0 kb | Distal (>10kb) Multiome | 892 | |
| chr14:24,315,948–24,316,753 | 126.4 kb | Distal (>10kb) Multiome | 736 | |
| chr14:24,332,251–24,333,127 | 110.2 kb | Distal (>10kb) Multiome | 740 | |
| chr14:24,365,652–24,366,243 | 77.0 kb | Distal (>10kb) Multiome | 668 | |
| chr14:24,366,594–24,369,358 | 75.6 kb | Distal (>10kb) Multiome | 921 | |
| chr14:24,388,547–24,389,510 | 53.8 kb | Distal (>10kb) Multiome | 161 | |
| chr14:24,398,424–24,399,423 | 43.8 kb | Distal (>10kb) Multiome | 354 | |
| chr14:24,429,597–24,431,070 | 12.7 kb | Distal (>10kb) Multiome | 903 | |
| chr14:24,431,554–24,432,205 | 10.8 kb | Distal (>10kb) Multiome | 604 | |
| chr14:24,436,789–24,436,996 | 5.8 kb | Proximal (<10kb) | 265 | |
| chr14:24,441,935–24,443,373 | 131 bp | At TSS Multiome | 1072 | |
| chr14:24,481,599–24,482,121 | 39.0 kb | Distal (>10kb) Multiome | 593 |
Genomic view of the SDR39U1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.