Predicted to enable calcium ion binding activity; hedgehog family protein binding activity; and lipid binding activity. Predicted to be involved in signal transduction. Predicted to act upstream of or within several processes, including chondrocyte differentiation involved in endochondral bone morphogenesis; positive regulation of chondrocyte proliferation; and positive regulation of osteoblast differentiation. Predicted to be located in extracellular region. Predicted to be active in cell surface and extracellular space. [provided by Alliance of Genome Resources, Apr 2025]
Transcription factors with Perturb-seq knockdown data for SCUBE2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SCUBE2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SCUBE2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:8,810,380–8,811,275 | 280.8 kb | Distal (>10kb) Multiome | 360 | |
| chr11:8,813,629–8,814,688 | 277.7 kb | Distal (>10kb) Multiome | 380 | |
| chr11:8,870,357–8,871,640 | 220.6 kb | Distal (>10kb) Multiome | 506 | |
| chr11:8,910,714–8,911,839 | 180.3 kb | Distal (>10kb) Multiome | 722 | |
| chr11:8,963,907–8,965,344 | 127.1 kb | Distal (>10kb) Multiome | 912 | |
| chr11:9,003,516–9,004,824 | 87.6 kb | Distal (>10kb) Multiome | 534 | |
| chr11:9,090,882–9,091,926 | 12 bp | At TSS Multiome | 196 | |
| chr11:9,137,773–9,138,204 | at TSS | At TSS | 284 | |
| chr11:9,264,697–9,266,230 | 173.9 kb | Distal (>10kb) Multiome | 703 | |
| chr11:9,313,980–9,315,407 | 223.2 kb | Distal (>10kb) Multiome | 997 | |
| chr11:9,363,967–9,364,851 | 272.9 kb | Distal (>10kb) Multiome | 1019 | |
| chr11:9,384,450–9,385,531 | 293.1 kb | Distal (>10kb) Multiome | 939 |
Genomic view of the SCUBE2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.