This gene encodes a protein that was identified as being similar to the Drosophila scribble protein. The mammalian protein is involved in tumor suppression pathways. As a scaffold protein involved in cell polarization processes, this protein binds to many other proteins. The encoded protein binds to papillomavirus E6 protein via its PDZ domain and the C-terminus of E6. Two alternatively spliced transcript variants that encode different protein isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
Transcription factors with Perturb-seq knockdown data for SCRIB. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SCRIB upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SCRIB, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:143,540,714–143,542,061 | 273.9 kb | Distal (>10kb) Multiome | 849 | |
| chr8:143,553,122–143,554,177 | 261.6 kb | Distal (>10kb) Multiome | 775 | |
| chr8:143,558,225–143,558,936 | 256.9 kb | Distal (>10kb) Multiome | 600 | |
| chr8:143,567,166–143,570,227 | 246.2 kb | Distal (>10kb) Multiome | 485 | |
| chr8:143,571,367–143,572,283 | 243.6 kb | Distal (>10kb) Multiome | 443 | |
| chr8:143,577,641–143,578,799 | 237.0 kb | Distal (>10kb) Multiome | 470 | |
| chr8:143,596,744–143,599,643 | 217.8 kb | Distal (>10kb) Multiome | 973 | |
| chr8:143,608,979–143,610,357 | 205.6 kb | Distal (>10kb) Multiome | 735 | |
| chr8:143,617,068–143,618,380 | 197.7 kb | Distal (>10kb) Multiome | 823 | |
| chr8:143,635,715–143,636,601 | 179.4 kb | Distal (>10kb) Multiome | 786 | |
| chr8:143,684,308–143,684,747 | 130.9 kb | Distal (>10kb) Multiome | 686 | |
| chr8:143,716,075–143,716,913 | 99.1 kb | Distal (>10kb) Multiome | 311 | |
| chr8:143,733,345–143,734,440 | 81.6 kb | Distal (>10kb) Multiome | 663 | |
| chr8:143,740,039–143,740,754 | 74.9 kb | Distal (>10kb) Multiome | 308 | |
| chr8:143,771,202–143,772,221 | 43.6 kb | Distal (>10kb) Multiome | 405 | |
| chr8:143,814,945–143,816,493 | 398 bp | At TSS Multiome | 893 | |
| chr8:143,828,724–143,829,946 | 14.0 kb | Distal (>10kb) Multiome HiCAR | 933 | |
| chr8:143,840,284–143,841,979 | 25.7 kb | Distal (>10kb) Multiome | 551 | |
| chr8:143,877,814–143,879,346 | 63.2 kb | Distal (>10kb) Multiome | 444 | |
| chr8:143,941,814–143,942,929 | 126.9 kb | Distal (>10kb) Multiome | 630 | |
| chr8:143,943,562–143,944,432 | 128.7 kb | Distal (>10kb) Multiome | 587 | |
| chr8:143,951,583–143,954,394 | 138.4 kb | Distal (>10kb) Multiome | 943 | |
| chr8:143,972,817–143,973,908 | 158.2 kb | Distal (>10kb) Multiome | 436 | |
| chr8:143,976,288–143,977,568 | 161.7 kb | Distal (>10kb) Multiome | 738 | |
| chr8:143,989,521–143,991,038 | 174.7 kb | Distal (>10kb) Multiome | 596 | |
| chr8:144,049,063–144,051,761 | 235.3 kb | Distal (>10kb) Multiome | 342 | |
| chr8:144,060,259–144,061,087 | 245.4 kb | Distal (>10kb) Multiome | 727 | |
| chr8:144,078,142–144,079,235 | 263.3 kb | Distal (>10kb) Multiome | 912 | |
| chr8:144,082,187–144,083,105 | 267.2 kb | Distal (>10kb) Multiome | 763 | |
| chr8:144,094,454–144,095,491 | 279.6 kb | Distal (>10kb) Multiome | 798 | |
| chr8:144,103,485–144,105,242 | 289.0 kb | Distal (>10kb) Multiome | 1033 | |
| chr8:144,108,038–144,108,663 | 293.0 kb | Distal (>10kb) Multiome | 137 |
Genomic view of the SCRIB locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.