The protein encoded by this gene is similar to SCARF1/SREC-I, a scavenger receptor protein that mediates the binding and degradation of acetylated low density lipoprotein (Ac-LDL). This protein has only little activity of internalizing modified low density lipoproteins (LDL), but it can interact with SCARF1 through its extracellular domain. The association of this protein with SCARF1 is suppressed by the presence of scavenger ligands. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for SCARF2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SCARF2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SCARF2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr22:20,203,393–20,204,086 | 234.0 kb | Distal (>10kb) Multiome | 292 | |
| chr22:20,243,636–20,244,300 | 193.8 kb | Distal (>10kb) Multiome | 251 | |
| chr22:20,267,373–20,268,700 | 169.4 kb | Distal (>10kb) Multiome | 449 | |
| chr22:20,298,366–20,300,076 | 138.7 kb | Distal (>10kb) Multiome | 538 | |
| chr22:20,319,527–20,320,815 | 117.7 kb | Distal (>10kb) Multiome | 805 | |
| chr22:20,393,744–20,394,682 | 43.7 kb | Distal (>10kb) Multiome | 854 | |
| chr22:20,418,190–20,418,662 | 19.4 kb | Distal (>10kb) Multiome | 594 | |
| chr22:20,429,261–20,429,681 | 8.1 kb | Proximal (<10kb) | 314 | |
| chr22:20,430,502–20,431,362 | 6.5 kb | Proximal (<10kb) | 317 | |
| chr22:20,431,567–20,432,135 | 6.0 kb | Proximal (<10kb) Multiome | 135 | |
| chr22:20,436,237–20,436,725 | 1.1 kb | Proximal (<10kb) | 249 | |
| chr22:20,437,361–20,438,451 | 132 bp | At TSS Multiome | 393 | |
| chr22:20,495,029–20,496,932 | 58.0 kb | Distal (>10kb) Multiome | 1018 | |
| chr22:20,507,376–20,507,935 | 69.8 kb | Distal (>10kb) Multiome | 894 | |
| chr22:20,606,015–20,606,540 | 168.5 kb | Distal (>10kb) Multiome | 411 | |
| chr22:20,702,218–20,703,674 | 265.2 kb | Distal (>10kb) Multiome | 438 |
Genomic view of the SCARF2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.