Transcription factors with Perturb-seq knockdown data for SCAMP1-AS1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SCAMP1-AS1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SCAMP1-AS1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:78,294,105–78,295,966 | 65.8 kb | Distal (>10kb) Multiome | 936 | |
| chr5:78,359,821–78,361,240 | 221 bp | At TSS Multiome | 965 | |
| chr5:78,499,278–78,500,053 | 139.2 kb | Distal (>10kb) Multiome | 122 | |
| chr5:78,631,764–78,632,823 | 271.7 kb | Distal (>10kb) Multiome | 145 | |
| chr5:78,647,879–78,649,652 | 288.3 kb | Distal (>10kb) Multiome | 642 |
Genomic view of the SCAMP1-AS1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.