Transcription factors with Perturb-seq knockdown data for SBNO1-AS1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SBNO1-AS1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SBNO1-AS1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:123,150,285–123,151,740 | 213.9 kb | Distal (>10kb) Multiome | 487 | |
| chr12:123,232,511–123,233,923 | 131.8 kb | Distal (>10kb) Multiome | 1073 | |
| chr12:123,269,375–123,269,864 | 95.2 kb | Distal (>10kb) Multiome | 217 | |
| chr12:123,270,951–123,272,226 | 93.7 kb | Distal (>10kb) Multiome | 488 | |
| chr12:123,363,804–123,365,980 | 180 bp | At TSS Multiome | 1015 | |
| chr12:123,383,367–123,384,963 | 19.0 kb | Distal (>10kb) Multiome | 836 | |
| chr12:123,388,500–123,389,409 | 23.9 kb | Distal (>10kb) Multiome | 446 | |
| chr12:123,436,072–123,436,895 | 71.7 kb | Distal (>10kb) Multiome | 742 | |
| chr12:123,458,045–123,458,697 | 93.5 kb | Distal (>10kb) Multiome | 925 | |
| chr12:123,533,444–123,534,540 | 169.0 kb | Distal (>10kb) Multiome | 718 | |
| chr12:123,583,890–123,585,003 | 219.5 kb | Distal (>10kb) Multiome | 928 | |
| chr12:123,601,617–123,602,401 | 237.1 kb | Distal (>10kb) Multiome | 1076 | |
| chr12:123,633,273–123,633,970 | 268.8 kb | Distal (>10kb) Multiome | 886 |
Genomic view of the SBNO1-AS1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.