Transcription factors with Perturb-seq knockdown data for SBF2-AS1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SBF2-AS1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SBF2-AS1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:9,460,209–9,461,643 | 297.4 kb | Distal (>10kb) Multiome | 1040 | |
| chr11:9,572,794–9,575,580 | 182.9 kb | Distal (>10kb) Multiome | 1075 | |
| chr11:9,613,193–9,614,617 | 144.1 kb | Distal (>10kb) Multiome | 997 | |
| chr11:9,626,920–9,627,395 | 131.1 kb | Distal (>10kb) Multiome | 172 | |
| chr11:9,663,540–9,664,862 | 94.2 kb | Distal (>10kb) Multiome | 597 | |
| chr11:9,757,927–9,759,329 | 12 bp | At TSS Multiome | 865 | |
| chr11:9,922,650–9,923,161 | 164.7 kb | Distal (>10kb) Multiome | 154 | |
| chr11:9,982,795–9,983,783 | 225.1 kb | Distal (>10kb) Multiome | 255 | |
| chr11:10,293,485–10,294,954 | 535.8 kb | Distal (>10kb) Multiome HiCAR | 728 | |
| chr11:10,303,927–10,306,992 | 546.7 kb | Distal (>10kb) Multiome HiCAR | 897 | |
| chr11:10,307,252–10,308,323 | 549.7 kb | Distal (>10kb) Multiome HiCAR | 800 | |
| chr11:10,309,037–10,310,838 | 551.4 kb | Distal (>10kb) Multiome HiCAR | 494 |
Genomic view of the SBF2-AS1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.