WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein with two WW domains, a SARAH domain, and a coiled-coil region and is ubiquitously expressed in adult tissues. This protein binds to MST1 (mammalian sterile 20-like kinase 1) and promotes MST1-induced apoptosis. It has also been shown to bind to HAX1 (hematopoietic cell-specific protein 1 (HS1)-associated protein X-1) and to attenuate the anti-apoptotic effects of HAX1. Studies in human and mouse suggest this gene acts as a tumor suppressor. [provided by RefSeq, Aug 2012]
Transcription factors with Perturb-seq knockdown data for SAV1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SAV1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SAV1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:50,396,285–50,397,366 | 271.5 kb | Distal (>10kb) Multiome | 782 | |
| chr14:50,531,734–50,533,317 | 135.7 kb | Distal (>10kb) Multiome | 905 | |
| chr14:50,559,970–50,561,283 | 107.7 kb | Distal (>10kb) Multiome | 524 | |
| chr14:50,667,319–50,668,903 | 23 bp | At TSS Multiome | 914 | |
| chr14:50,823,525–50,824,353 | 155.6 kb | Distal (>10kb) Multiome | 183 | |
| chr14:50,829,783–50,831,951 | 162.9 kb | Distal (>10kb) Multiome | 634 | |
| chr14:50,871,977–50,872,487 | 203.9 kb | Distal (>10kb) Multiome | 114 | |
| chr14:50,943,178–50,945,258 | 276.2 kb | Distal (>10kb) Multiome | 823 |
Genomic view of the SAV1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.