Transcription factors with Perturb-seq knockdown data for SATB2-AS1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SATB2-AS1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SATB2-AS1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:199,455,411–199,456,654 | 1.0 kb | Proximal (<10kb) | 863 | |
| chr2:199,456,911–199,460,483 | at TSS | At TSS | 1064 | |
| chr2:199,461,810–199,465,006 | 4.1 kb | Proximal (<10kb) | 700 | |
| chr2:199,466,045–199,466,262 | 8.4 kb | Proximal (<10kb) | 26 | |
| chr2:199,466,565–199,466,722 | 8.9 kb | Proximal (<10kb) | 20 | |
| chr2:199,466,957–199,467,868 | 9.3 kb | Proximal (<10kb) | 138 | |
| chr2:199,468,395–199,470,562 | 8.6 kb | Proximal (<10kb) | 280 |
Genomic view of the SATB2-AS1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.