Predicted to be involved in negative regulation of DNA-templated transcription. Predicted to be located in cytoplasm. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for SAP25. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SAP25 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SAP25, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:100,335,652–100,336,470 | 237.8 kb | Distal (>10kb) Multiome | 706 | |
| chr7:100,381,682–100,382,670 | 191.6 kb | Distal (>10kb) Multiome | 49 | |
| chr7:100,428,059–100,431,175 | 145.5 kb | Distal (>10kb) Multiome | 1296 | |
| chr7:100,435,379–100,436,927 | 137.3 kb | Distal (>10kb) Multiome | 931 | |
| chr7:100,450,379–100,450,973 | 123.2 kb | Distal (>10kb) Multiome | 785 | |
| chr7:100,478,582–100,479,753 | 94.5 kb | Distal (>10kb) Multiome HiCAR | 842 | |
| chr7:100,482,937–100,484,533 | 90.3 kb | Distal (>10kb) Multiome | 677 | |
| chr7:100,538,557–100,539,759 | 34.9 kb | Distal (>10kb) Multiome | 858 | |
| chr7:100,563,960–100,564,138 | 8.9 kb | Proximal (<10kb) | 254 | |
| chr7:100,569,177–100,570,642 | 4.2 kb | Proximal (<10kb) Multiome | 855 | |
| chr7:100,571,007–100,573,075 | at TSS | At TSS | 388 | |
| chr7:100,573,670–100,574,027 | 604 bp | At TSS | 170 | |
| chr7:100,585,161–100,587,241 | 12.5 kb | Distal (>10kb) Multiome | 966 | |
| chr7:100,611,685–100,612,981 | 38.4 kb | Distal (>10kb) Multiome | 767 | |
| chr7:100,626,427–100,627,057 | 52.9 kb | Distal (>10kb) Multiome | 415 | |
| chr7:100,656,111–100,656,626 | 82.5 kb | Distal (>10kb) Multiome | 653 | |
| chr7:100,673,043–100,674,892 | 99.6 kb | Distal (>10kb) Multiome | 934 | |
| chr7:100,674,996–100,676,406 | 102.1 kb | Distal (>10kb) Multiome | 439 | |
| chr7:100,691,570–100,692,163 | 118.0 kb | Distal (>10kb) Multiome | 364 | |
| chr7:100,693,475–100,694,667 | 120.4 kb | Distal (>10kb) Multiome | 607 | |
| chr7:100,705,140–100,706,426 | 132.0 kb | Distal (>10kb) Multiome | 962 | |
| chr7:100,827,001–100,828,324 | 253.8 kb | Distal (>10kb) Multiome | 794 | |
| chr7:100,835,906–100,837,766 | 263.7 kb | Distal (>10kb) Multiome | 766 | |
| chr7:100,852,057–100,853,190 | 278.6 kb | Distal (>10kb) Multiome | 805 |
Genomic view of the SAP25 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.