This gene encodes a protein that contains a RUN (RPIP8, UNC-14 and NESCA) domain and a coiled coil domain. The encoded protein may negatively regulate p53 transcriptional activity. This gene is a potential candidate gene for predisposition to glioma in humans. [provided by RefSeq, May 2017]
Transcription factors with Perturb-seq knockdown data for RUNDC1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RUNDC1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RUNDC1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:42,682,736–42,683,400 | 297.8 kb | Distal (>10kb) Multiome | 480 | |
| chr17:42,744,352–42,745,375 | 235.6 kb | Distal (>10kb) Multiome | 966 | |
| chr17:42,761,003–42,761,468 | 219.5 kb | Distal (>10kb) Multiome | 335 | |
| chr17:42,780,029–42,780,899 | 200.0 kb | Distal (>10kb) Multiome | 712 | |
| chr17:42,798,408–42,798,877 | 181.8 kb | Distal (>10kb) Multiome | 866 | |
| chr17:42,823,968–42,824,503 | 156.3 kb | Distal (>10kb) Multiome | 829 | |
| chr17:42,832,889–42,833,841 | 147.2 kb | Distal (>10kb) Multiome | 980 | |
| chr17:42,964,237–42,964,843 | 16.1 kb | Distal (>10kb) Multiome | 655 | |
| chr17:42,979,966–42,981,044 | 120 bp | At TSS Multiome | 843 | |
| chr17:42,997,598–42,998,917 | 17.7 kb | Distal (>10kb) Multiome | 1112 | |
| chr17:43,021,026–43,022,568 | 41.8 kb | Distal (>10kb) Multiome | 973 | |
| chr17:43,024,255–43,025,752 | 44.5 kb | Distal (>10kb) Multiome | 811 | |
| chr17:43,124,981–43,125,702 | 144.9 kb | Distal (>10kb) Multiome | 837 | |
| chr17:43,169,744–43,171,576 | 190.6 kb | Distal (>10kb) Multiome | 1018 | |
| chr17:43,211,494–43,212,392 | 231.4 kb | Distal (>10kb) Multiome | 586 |
Genomic view of the RUNDC1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.