RTN4R

reticulon 4 receptor | NOGOR, NgR, NgR1

This gene encodes the receptor for reticulon 4, oligodendrocyte myelin glycoprotein and myelin-associated glycoprotein. This receptor mediates axonal growth inhibition and may play a role in regulating axonal regeneration and plasticity in the adult central nervous system. [provided by RefSeq, Jul 2008]

Biological processes 55 terms

axon (GO:0030424)axonal growth cone (GO:0044295)axonal growth cone (GO:0044295)cell surface (GO:0009986)cell surface (GO:0009986)cell surface receptor signaling pathway (GO:0007166)chondroitin sulfate binding (GO:0035374)chondroitin sulfate binding (GO:0035374)corpus callosum development (GO:0022038)corpus callosum development (GO:0022038)dendrite (GO:0030425)dendritic shaft (GO:0043198)dendritic shaft (GO:0043198)endoplasmic reticulum (GO:0005783)external side of plasma membrane (GO:0009897)external side of plasma membrane (GO:0009897)extracellular exosome (GO:0070062)ganglioside GM1 binding (GO:1905573)ganglioside GM1 binding (GO:1905573)ganglioside GT1b binding (GO:1905576)ganglioside GT1b binding (GO:1905576)glutamatergic synapse (GO:0098978)growth cone (GO:0030426)heparin binding (GO:0008201)heparin binding (GO:0008201)membrane raft (GO:0045121)membrane raft (GO:0045121)negative regulation of axon extension (GO:0030517)negative regulation of axon extension (GO:0030517)negative regulation of axon regeneration (GO:0048681)negative regulation of axon regeneration (GO:0048681)negative regulation of neuron projection development (GO:0010977)negative regulation of neuron projection development (GO:0010977)neuregulin receptor activity (GO:0038131)neuregulin receptor activity (GO:0038131)neuron projection (GO:0043005)neuron projection (GO:0043005)neuronal cell body (GO:0043025)neuronal cell body (GO:0043025)neuronal signal transduction (GO:0023041)neuronal signal transduction (GO:0023041)perikaryon (GO:0043204)plasma membrane (GO:0005886)plasma membrane (GO:0005886)plasma membrane (GO:0005886)plasma membrane (GO:0005886)plasma membrane (GO:0005886)positive regulation of GTPase activity (GO:0043547)positive regulation of Rho protein signal transduction (GO:0035025)positive regulation of Rho protein signal transduction (GO:0035025)protein binding (GO:0005515)regulation of postsynapse assembly (GO:0150052)regulation of synapse assembly (GO:0051963)signaling receptor activity (GO:0038023)signaling receptor activity (GO:0038023)

Expression (TPM)

TFs regulating RTN4R 0 TFs

Transcription factors with Perturb-seq knockdown data for RTN4R. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RTN4R upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to RTN4R

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RTN4R, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr22:19,986,350–19,987,426	280.5 kb	Distal (>10kb) Multiome	539
chr22:20,016,068–20,017,437	250.8 kb	Distal (>10kb) Multiome	640
chr22:20,020,662–20,021,745	246.7 kb	Distal (>10kb) Multiome	718
chr22:20,079,663–20,080,743	187.6 kb	Distal (>10kb) Multiome	994
chr22:20,116,628–20,118,048	150.4 kb	Distal (>10kb) Multiome	999
chr22:20,130,806–20,131,896	136.5 kb	Distal (>10kb) Multiome	525
chr22:20,203,393–20,204,086	63.9 kb	Distal (>10kb) Multiome	292
chr22:20,238,620–20,238,836	4.8 kb	Proximal (<10kb)	323
chr22:20,243,636–20,244,300	23.7 kb	Distal (>10kb) Multiome	251
chr22:20,267,373–20,268,700	712 bp	At TSS Multiome	449
chr22:20,298,366–20,300,076	31.5 kb	Distal (>10kb) Multiome	538
chr22:20,319,527–20,320,815	52.4 kb	Distal (>10kb) Multiome	805
chr22:20,393,744–20,394,682	126.4 kb	Distal (>10kb) Multiome	854
chr22:20,418,190–20,418,662	150.7 kb	Distal (>10kb) Multiome	594
chr22:20,431,567–20,432,135	164.1 kb	Distal (>10kb) Multiome	135
chr22:20,437,361–20,438,451	170.3 kb	Distal (>10kb) Multiome	393
chr22:20,495,029–20,496,932	228.2 kb	Distal (>10kb) Multiome	1018
chr22:20,507,376–20,507,935	239.9 kb	Distal (>10kb) Multiome	894

Genome Browser

Genomic view of the RTN4R locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.