This gene belongs to the family of reticulon encoding genes. Reticulons are associated with the endoplasmic reticulum, and are involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells. This gene is considered to be a specific marker for neurological diseases and cancer, and is a potential molecular target for therapy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2011]
Transcription factors with Perturb-seq knockdown data for RTN1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RTN1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RTN1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:59,576,271–59,577,126 | 294.0 kb | Distal (>10kb) Multiome | 448 | |
| chr14:59,630,298–59,630,972 | 240.1 kb | Distal (>10kb) Multiome | 239 | |
| chr14:59,869,655–59,870,123 | 652 bp | At TSS | 143 | |
| chr14:59,870,241–59,871,387 | 34 bp | At TSS Multiome | 433 | |
| chr14:59,919,228–59,920,620 | 49.2 kb | Distal (>10kb) Multiome | 615 | |
| chr14:60,091,167–60,092,522 | 221.2 kb | Distal (>10kb) Multiome | 1039 | |
| chr14:60,164,676–60,165,904 | 294.6 kb | Distal (>10kb) Multiome | 793 |
Genomic view of the RTN1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.